This study evaluates whether a single dose of intranasal testosterone can improve neurological and autonomic nervous system (ANS) function in men with chronic spinal cord injury (SCI) and low testosterone levels. SCI can disrupt communication between the brain, spinal cord, and body, leading to impaired motor function, muscle weakness, and autonomic dysfunction affecting cardiovascular regulation. Because many men with SCI experience persistently low testosterone levels, researchers are investigating whether restoring testosterone levels may improve neural function.
Participants include men aged 18-80 with chronic SCI and low testosterone levels. They will receive either intranasal testosterone or a placebo. Researchers will evaluate changes in brain and spinal cord activity, muscle function, and cardiovascular reflex function using noninvasive neurophysiological assessments. The findings will help determine whether testosterone is a potential therapy to improve neurological function after SCI.
